Discover an Essential Tool for Your Diabetes Toolkit

Gvoke HypoPen^® is the ready-to-use rescue pen for low blood sugar emergencies that anyone can administer^1,2 including you — in certain situations

Why Do You Need Gvoke HypoPen?

During a severe low blood sugar event, you need a safety net for when it matters most

Managing blood sugar levels is challenging, no matter how dedicated you are to your treatment plan. Low blood sugar emergencies can happen unexpectedly and they demand quick action. That’s why it’s important for you and your loved ones to be ready to confidently treat severe low blood sugar.

*Store in original sealed pouch until time of use.

Meet Gvoke HypoPen

Gvoke HypoPen is the ready-to-use rescue pen anyone can administer¹ with confidence

Ready-to-Use Premixed and ready-to-go at a moment’s notice.³
Simple to Administer Anyone can administer in 2 simple steps^1,2,5 including you — in certain situations.
Proven to Work Brings very low blood sugar back up quickly and safely.^3†

Understanding Dosages

Gvoke HypoPen comes in two premeasured dosing options³

1 mg per 0.2 mL

For patients ages 12 and older, or children under 12 years old who weigh ≥ 100 lbs
Lasts 30 months from date of manufacture when stored at room temperature⁴

0.5 mg per 0.1 mL

For patients ages 2 to 11 who weigh < 100 lbs
Lasts 24 months from date of manufacture when stored at room temperature⁴

Proven safe

In clinical trials, most side effects were mild.^4*

The most common side effects in adults were³:

Nausea(30%)
Vomiting (16%)
Swelling at the injection site (7%)
Headache (5%)

The most common side effects in children were³:

Nausea (45%)
Hypoglycemia (39%)
Vomiting (19%)
Headache (7%)
Hyperglycemia (7%)
Abdominal pain (3%)
Injection site discomfort (3%)
Injection site reaction (3%)
Urticaria (hives) (3%)

*Mild side effects are those that do not interfere with your normal day-to-day functioning.

Know When To Use Gvoke HypoPen

Severe low blood sugar requires immediate attention. Gvoke HypoPen should be used if you experience any of the following during a low blood sugar emergency²:

Correcting with food or drink isn’t working
You are unable to swallow safely
You feel like passing out
You pass out or have a seizure

Where People Keep Gvoke HypoPen

Gvoke HypoPen comes in a convenient two-pack. You should have it available at all times no matter where you are. Store Gvoke HypoPen at room temperature (68°F to 77°F).³ Do not refrigerate or freeze.

Home

Keep Gvoke HypoPen in an easy-to-access location where you live (e.g. nightstand).

School or work

Ensure you have Gvoke HypoPen available to treat a severe low at school or the office.

On the go

Gvoke HypoPen is easy to travel with because it doesn’t need to be refrigerated.

†In two clinical studies in adults, blood sugar levels that were less than 50 mg/dL increased to above 70 mg/dL or increased by at least 20 mg/dL within 13.8 minutes on average.

REFERENCES:

Valentine V, Newswanger B, Prestrelski S, Andre AD, Garibaldi M. Human factors usability and validation studies of a glucagon autoinjector in a simulated severe hypoglycemia rescue situation. Diabetes Technol Ther. 2019;21(9):522-530
Gvoke HypoPen [instructions for use]. Chicago, IL: Xeris Pharmaceuticals, Inc.
Gvoke [prescribing information]. Chicago, IL: Xeris Pharmaceuticals, Inc.
Data on file. Xeris Pharmaceuticals, Inc.
Meyer JM, Devona MC. U.S. Survey investigating gaps between patients and specialists in the treatment of severe hypoglycemia and impressions of the ease-of-use of liquid-stable glucagon for subcutaneous injection. Int Arch Endocrinol Clin Res. 2021;7(1):025. doi:10.23937/2572-407X.1510025

Indication and Important Safety Information⁠—⁠Read More

INDICATION AND SAFETY SUMMARY

GVOKE is a prescription medicine used to treat very low blood sugar (severe hypoglycemia) in adults and kids with diabetes ages 2 years and above. It is not known if GVOKE is safe and effective in children under 2 years of age.

WARNINGS

Do not use GVOKE if:

you have a tumor in the gland on top of your kidneys (adrenal gland), called a pheochromocytoma.
you have a tumor in your pancreas called an insulinoma.
you are allergic to glucagon or any inactive ingredient in GVOKE.

GVOKE MAY CAUSE SERIOUS SIDE EFFECTS, INCLUDING:

High blood pressure
GVOKE can cause high blood pressure in certain people with tumors in their adrenal glands.

Low blood sugar
GVOKE can cause low blood sugar in certain people with tumors in their pancreas called insulinomas by making too much insulin in their bodies.

Serious allergic reaction
Call your doctor or get medical help right away if you have a serious allergic reaction including:

rash
difficulty breathing
low blood pressure

COMMON SIDE EFFECTS

The most common side effects of GVOKE in adults include:

nausea
vomiting
swelling at the injection site
headache

The most common side effects of GVOKE in children include:

nausea
low blood sugar
high blood sugar
vomiting
abdominal pain
headache
pain or redness at the injection site
itching

These are not all the possible side effects of GVOKE. For more information, ask your doctor. Call your doctor for medical advice about side effects.

You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

BEFORE USING

Before using GVOKE, tell your healthcare provider about all your medical conditions, including if you:

have adrenal gland problems
have a tumor in your pancreas
have not had food or water for a long time (prolonged fasting or starvation)
have low blood sugar that does not go away (chronic hypoglycemia)
are pregnant or plan to become pregnant
are breastfeeding or plan to breastfeed. It is not known if GVOKE passes into your breast milk. You and your healthcare provider should decide if you can use GVOKE while breastfeeding.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

HOW TO USE

Read the detailed Instructions for Use that come with GVOKE.
Use GVOKE exactly how your healthcare provider tells you to use it
Make sure your relatives, close friends, and caregivers know where you store GVOKE and how to use it the right way before you need their help.
Act quickly. Having very low blood sugar for a period of time may be harmful.
Your healthcare provider will tell you how and when to use GVOKE.
After giving GVOKE, your caregiver should call for emergency medical help right away.
If you do not respond after 15 minutes, your caregiver may give you another dose, if available. Tell your healthcare provider each time you use GVOKE. Low blood sugar may happen again after receiving an injection of GVOKE. Your diabetes medicine may need to be changed.

HOW TO STORE

Keep GVOKE pre-filled syringe and HypoPen in sealed foil pouch until time of use.
Keep GVOKE kit vial and pouched syringe together in original carton until time of use.
Store GVOKE at temperatures between 68°F and 77°F.
Do not keep it in the refrigerator or let it freeze.

Keep GVOKE and all medicines out of the reach of children.

For more information, call 1-877-937-4737 or go to www.GvokeGlucagon.com.

Please see the Full Prescribing Information for Gvoke

Gvoke®, Gvoke HypoPen®, Xeris Pharmaceuticals®, the droplet design, and their associated logos are trademarks of Xeris Pharmaceuticals, Inc. All other trademarks are property of their respective owners.

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