100% treatment success* with a single dose in kids¹

Gvoke brought blood sugar back up to safe levels^1,†

In a clinical study, Gvoke brought every kid out of their low blood sugar event.^‡

Average increase in blood sugar for kids 2-5 years old of 81 mg/dL.

The average increase in blood sugar for kids 2-5 years old half an hour after using Gvoke (0.5 mg/0.1 mL dose)¹

● Kids in this age group saw an average peak blood sugar increase of 134 mg/dL after using Gvoke

Average increase in blood sugar for kids 6-11 years old of 84 mg/dL.

The average increase in blood sugar for kids 6-11 years old half an hour after using Gvoke (0.5 mg/0.1 mL dose)¹

● Kids in this age group saw an average peak blood sugar increase of 145 mg/dL after using Gvoke

Average peak increase in blood sugar for kids 12-17 years of 53-55 mg/dL.

The average increase in blood sugar for kids 12-17 years old half an hour after using Gvoke (53 mg/dL for kids who took the 0.5 mg/0.1 mL dose; 55 mg/dL for kids who took the 1.0 mg/0.2 mL dose)¹

● Kids in this age group saw an average peak blood sugar increase of 123 mg/dL after using Gvoke

It's important to remember that not every situation is the same and results may vary based on certain factors such as how low the blood sugar gets, how much insulin has been taken, and how many carbohydrates are in the body.

*Treatment success was achieved if a person experienced a plasma glucose increase of at least 25 mg/dL.¹

^†Gvoke was shown to sufficiently increase blood sugar levels in 3 different age ranges.

^‡Low blood sugar was defined as <80 mg/dL.

Reference: 1. Gvoke [prescribing information]. Chicago, IL: Xeris Pharmaceuticals, Inc; 2021.

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SAFETY

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INDICATION AND SAFETY SUMMARY

GVOKE is a prescription medicine used to treat very low blood sugar (severe hypoglycemia) in adults and kids with diabetes ages 2 years and above. It is not known if GVOKE is safe and effective in children under 2 years of age.

WARNINGS

Do not use GVOKE if:

you have a tumor in the gland on top of your kidneys (adrenal gland), called a pheochromocytoma.
you have a tumor in your pancreas called an insulinoma.
you are allergic to glucagon or any other inactive ingredient in GVOKE.

GVOKE MAY CAUSE SERIOUS SIDE EFFECTS, INCLUDING:

High blood pressure. GVOKE can cause high blood pressure in certain people with tumors in their adrenal glands.

Low blood sugar. GVOKE can cause low blood sugar in certain people with tumors in their pancreas called insulinomas by making too much insulin in their bodies.

Serious allergic reaction. Call your doctor or get medical help right away if you have a serious allergic reaction including:

rash
difficulty breathing
low blood pressure

COMMON SIDE EFFECTS

The most common side effects of GVOKE in adults include:

nausea
vomiting
swelling at the injection site
headache

The most common side effects of GVOKE in children include:

nausea
low blood sugar
high blood sugar
vomiting
abdominal pain
headache
pain or redness at the injection site
itching

These are not all the possible side effects of GVOKE. For more information, ask your doctor. Call your doctor for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1‑800‑FDA‑10881‑800‑FDA‑1088.

BEFORE USING

Before using GVOKE, tell your doctor about all your medical conditions, including if you:

have adrenal gland problems
have a tumor in your pancreas
have not had food or water for a long time (prolonged fasting or starvation)
have low blood sugar that does not go away (chronic hypoglycemia)
are pregnant or plan to become pregnant
are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

HOW TO USE

Read the detailed Instructions for Use that come with GVOKE.
Use GVOKE exactly how your healthcare provider tells you to use it
Make sure your relatives, close friends, and caregivers know where you store GVOKE and how to use it the right way before you need their help.
Act quickly. Having very low blood sugar for a period of time may be harmful.
Your healthcare provider will tell you how and when to use GVOKE.
After giving GVOKE, your caregiver should call for emergency medical help right away.
If you do not respond after 15 minutes, your caregiver may give you another dose, if available. Tell your healthcare provider each time you use GVOKE. Low blood sugar may happen again after receiving an injection of GVOKE. Your diabetes medicine may need to be changed.

HOW TO STORE

Keep GVOKE in the foil pouch until you are ready to use it.
Store GVOKE at temperatures between 68°F and 77°F.
Do not keep it in the refrigerator or let it freeze.

Keep GVOKE and all medicines out of the reach of children.

For more information, call 1-877-937-47371-877-937-4737 or go to www.GvokeGlucagon.com.

Please see the Important Facts about Gvoke.